活力藥師網

最近在網路上看到一些關於波斯卡的文章，居然提到女性也可以吃波斯卡，我就非常有興趣，如果這是真的，那一些女性同胞們就可以擁有一頭茂密的長髮了；於是我在Google大神的指導下，打入”proscar+female”，出現了底下這篇文章

Effect of finasteride 5 mg (Proscar) on acne and alopecia in female patients with normal serum levels of free testosterone.

看標題似乎很清楚的是說，女性朋友服用波斯卡也會有效果才對，我們來看一下摘要!!

BACKGROUND: In some women with acne or alopecia who have normal serum levels of free testosterone, no clinical improvement can be reached by the classical treatment with antiandrogens, isotretinoids or corticosteroids. Our hypothesis is that some of these women have an excessive activity of the enzyme 5alpha-reductase.

OBJECTIVE: To evaluate the subjective benefit of the treatment with finasteride (5 mg/day) in women with normal serum levels of free testosterone suffering from acne or alopecia.

評估投予5mg的finasteride(也就是波斯卡)是否能對這些女性產生幫助。

DESIGN: This was a retrospective study evaluating a questionnaire filled out by 12 patients, six of whom had acne and six of whom had alopecia.RESULTS: Nine of the 12 patients benefited from the treatment, their symptoms decreased significantly and they felt better psychologically than before the administration of finasteride. The other three patients did not benefit at all from finasteride and reported no change in the extent of the acne/alopecia. Treatment was generally well tolerated, only a few adverse effects were noted.

實驗的設計有根本上的問題，首先此實驗為回溯性之問卷調查，只是調查而且又是回溯性的，我現在問你去年吃過什麼早餐，你會記得嗎???病人可能記得，也可能因為不想回答而亂作答!!!更可笑的是病人只有12個人而已!!!(未免太偷懶了)

CONCLUSIONS: Nine of the 12 patients benefited from the treatment. This supports our hypothesis of an excessive activity of 5alpha-reductase enzyme in peripheral tissue in these patients. The fact that three of the patients did not realize any change in their symptom severity implies that there must also be other pathways in the genesis of acne and alopecia in women with normal levels of free testosterone. Further evaluation is needed to elucidate more precise indications for the administration of finasteride in women with acne and alopecia.

這篇文章告訴我們讀paper的時候要非常小心才是!!!

結論:女性朋友還是不能服用波斯卡!!

那女性如果不能服用波斯卡，那男性服用時候，可以讓太太懷孕嗎??